Question 1

What are Polynucleotides?

Accepted Answer

Polynucleotides are biocompatible, non-immunogenic molecules derived from purified DNA. In aesthetic medicine, injectable polynucleotides are widely recognised for their ability to repair tissue, stimulate fibroblast activity, and boost collagen and elastin production. This makes them an advanced solution for improving skin elasticity, skin hydration, and overall skin quality.

Question 2

What is the difference between Polynucleotides and skin booster injections?

Accepted Answer

Both treatments improve skin hydration, but Polynucleotides go beyond traditional skin boosters. While skin boosters temporarily plump and hydrate the skin, polynucleotides regenerate skin cells at a deeper level, stimulating fibroblasts, collagen, and elastin for longer-lasting results.

Question 3

How do Polynucleotides differ from dermal fillers or anti-wrinkle injections?

Accepted Answer

Polynucleotide treatments are regenerative rather than corrective. Unlike fillers, which add volume, or anti-wrinkle injections, which relax facial muscles, injectable polynucleotides work by repairing and rejuvenating the skin from within. They improve skin hydration, elasticity, and texture over time, delivering natural and gradual results.

Question 4

What skin concerns can Polynucleotide treatments address?

Accepted Answer

Polynucleotide injections are highly versatile and can treat a wide range of concerns, including:Fine lines and wrinklesDull or dehydrated skinScars and acne scarringRosacea and inflammationSkin laxity and loss of elasticityDark circles and under-eye hollowsThey are suitable for most skin types and provide an excellent option for those looking for skin regeneration without altering facial structure.

Question 5

How many Polynucleotide treatments are needed to see results?

Accepted Answer

Most patients notice initial improvements in skin texture and hydration around 4 weeks after treatment. However, the most visible results are typically seen 6–8 weeks after the second session. A course of 3–4 treatments is usually recommended for optimal, long-lasting results.

Question 6

How is the Polynucleotide procedure performed?

Accepted Answer

The treatment is delivered through a series of micro-injections beneath the skin. These injections are minimally invasive and designed to distribute the product evenly for maximum effectiveness. Each session usually takes around 30–45 minutes, depending on the treatment area.

Question 7

Is the Polynucleotide treatment painful?

Accepted Answer

Most patients report minimal discomfort during the procedure. A topical numbing cream is applied before treatment, and very fine needles are used, making the injections well tolerated. Mild redness or swelling may occur but typically resolves quickly.

Question 8

How long do Polynucleotide results last?

Accepted Answer

Results usually last 6 to 12 months, depending on factors such as age, lifestyle, and the skin concerns being treated. Maintenance sessions are recommended to prolong results and continue stimulating skin regeneration

Question 9

Can Polynucleotides be combined with other aesthetic treatments?

Accepted Answer

Yes. Polynucleotide treatments complement other injectable skin boosters, dermal fillers, and anti-wrinkle injections. They are often combined with treatments such as Profhilo, microneedling, or laser therapy for enhanced results and overall facial rejuvenation.

Question 10

What is the pre-treatment advice before Polynucleotides?

Accepted Answer

To ensure your safety please follow the advice:Be mindful when planning social events because following your Injectable treatment you may have redness, bruising, compromised skin and/or swelling.Bruising and unwanted side effects can occur at any time even if you have had the treatment done without any concerns prior.Please let your Consultant Healthcare Professional (HCP) know if you are planning to travel in the next 4 weeks. You must not have any active cold sores on the day of treatment. If you are prone to cold sores, discuss this with your Consultant HCP at Therapie Clinic. You have no active acne at in the injection area.You have had no recent illness, including infections or antibiotic treatment.You are not pregnant, trying to conceive or breastfeeding.You understand that this is a 3-4 treatment protocol and to receive optimum results you must complete the course of treatments and then maintain throughout the year.You understand that this treatment does not have instant results and results can take up to 6 weeks to be seen. Results can vary.Inform your HCP of any medications, vitamins and/or supplements you are taking. Many of these thin the blood that can lead to more bruising than normal. If you are taking blood thinning medications like Aspirin or Warfarin, please inform your HCP as these medications can increase bruising. It is important that on the day of treatment you come with no makeup on, you must not reapply makeup for 24 hours to reduce the risk of infection or irritation to the skin.

Question 11

Are Polynucleotides safe?

Accepted Answer

Yes. Polynucleotides are highly biocompatible and non-immunogenic, meaning they are safe and well tolerated by the body. Side effects such as redness, swelling, or mild bruising are temporary and usually resolve within a few days.

Question 12

Where can Polynucleotides be used?

Accepted Answer

Polynucleotide injections are most commonly used on the face, under-eye area, neck, décolleté, and hands. They are especially effective in delicate areas where skin is thin and prone to ageing, such as the under eyes.

Question 13

Polynucleotides vs Profhilo – which is better?

Accepted Answer

Both treatments are excellent for skin rejuvenation, but they work differently. Profhilo delivers hyaluronic acid for deep hydration and improved firmness, while Polynucleotides stimulate skin cells to regenerate, repair, and produce collagen and elastin. Many patients choose to combine the two for maximum results.

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